Paper
Derivatives of Diphenylsulfone, Related Sulfoxides and Sulfides in Experimental Tuberculosis.∗
Published Nov 1, 1946 · DOI · B. L. Freedlander, F. French
Proceedings of the Society for Experimental Biology and Medicine
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Abstract
Summary A series of derivatives of diphenyl sulfone, sulfoxide and sulfide were tested for in vitro tuberculostatic activity and for antituberculous therapeutic activity in guinea pigs. The following compounds, in addition to the reference materials 4, 4′-diaminodiphenylsulfone and its derivative diasone, showed high in vivo activity: 4-benzylideneamino, 4-aminodiphenylsulfone; 4-nitro, 4-acetylaminodiphenylsuLfone; 4, 4-di-aminodiphenylsulfoxide (hypo); 4, 4-diacetyl-aminodiphenylsulfoxide (oral). 4-Chloro, 4-aminodiphenylsulfide and the corresponding iodo derivative were highly tuberculostatic in vitro but were devoid of in vivo activity.
Diphenyl sulfone derivatives show high in vivo antituberculous activity, while 4-chloro, 4-aminodiphenylsulfide and its iodo derivative show in vitro tuberculostatic activity but no in vivo activity.
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