Design of molecular hybrids of phthalimide-triazole agents with potent selective MCF-7/HepG2 cytotoxicity: Synthesis, EGFR inhibitory effect, and metabolic stability.

doi:10.1016/j.bioorg.2021.104835

Paper

Design of molecular hybrids of phthalimide-triazole agents with potent selective MCF-7/HepG2 cytotoxicity: Synthesis, EGFR inhibitory effect, and metabolic stability.

Published Mar 22, 2021 · Saleh K Ihmaid, Shaya Y. Alraqa, M. Aouad

Bioorganic chemistry

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47

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1

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Abstract

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In Vitro Study

Study Snapshot

This study synthesized potent selective anticancer phthalimide-triazole leads with good metabolic stability and long duration behavior, offering promising leads for further cancer drug discovery.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Design of molecular hybrids of phthalimide-triazole agents with potent selective MCF-7/HepG2 cytotoxicity: Synthesis, EGFR inhibitory effect, and metabolic stability.

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