Design, structure-activity relationship, and highly efficient asymmetric synthesis of 3-phenyl-4-benzylaminopiperidine derivatives as novel neurokinin-1 receptor antagonists.

doi:10.1016/j.bmc.2011.08.070

Paper

Design, structure-activity relationship, and highly efficient asymmetric synthesis of 3-phenyl-4-benzylaminopiperidine derivatives as novel neurokinin-1 receptor antagonists.

Published Nov 1, 2011 · Junya Shirai, T. Yoshikawa, M. Yamashita

Bioorganic & medicinal chemistry

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5

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Abstract

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In Vitro Study

Study Snapshot

Novel 3-phenyl-4-benzylaminopiperidine derivatives show potent tachykinin NK 1 receptor antagonist activity and high metabolic stability, with efficient asymmetric synthesis achieved via dynamic kinetic resolution.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Design, structure-activity relationship, and highly efficient asymmetric synthesis of 3-phenyl-4-benzylaminopiperidine derivatives as novel neurokinin-1 receptor antagonists.

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