Design and synthesis of 2,4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents.

doi:10.1016/j.bmc.2009.11.061

Paper

Design and synthesis of 2,4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents.

Published Jun 1, 2010 · Atul Kumar, Siddhartha Sharma, V. Tripathi

Bioorganic & medicinal chemistry

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87

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Abstract

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In Vitro Study

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Study Snapshot

2,4-disubstituted polyhydroquinolines show promising antihyperglycemic and lipid modulating activities, with compounds 3a-r showing PTP1B inhibitory activity and compounds 5a-d showing glycogen phosphorylase activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Design and synthesis of 2,4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents.

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