Design, synthesis and anti-microbial activity of 1H-pyrazole carboxylates.

doi:10.1002/CHIN.200516108

Paper

DOI: 10.1002/CHIN.200516108

Design, synthesis and anti-microbial activity of 1H-pyrazole carboxylates.

Published Dec 20, 2004 · R. Sridhar, P. Perumal, S. Etti

Bioorganic & medicinal chemistry letters

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177

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Abstract

In a SAR study, we have synthesized a few 1H-pyrazole carboxylate related microbicides using Vilsmeier reagent. The anti-microbial screening results of 1H-pyrazole-3-carboxylate are reported here for the first time. The effect of 1H-pyrazole carboxylates on the mycelial growth of plant pathogenic fungi is revealed. The first X-ray structure in the family of microbicidal 1H-pyrazole-4-carboxylates is presented.

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1H-pyrazole carboxylates show promising anti-microbial activity and inhibit plant pathogenic fungi growth, with the first X-ray structure of 1H-pyrazole-4-carboxylates presented.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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