Design, synthesis, and biological activity of a novel series of 2,5-disubstituted furans/pyrroles as HIV-1 fusion inhibitors targeting gp41.

doi:10.1016/j.bmcl.2011.08.081

Paper

Design, synthesis, and biological activity of a novel series of 2,5-disubstituted furans/pyrroles as HIV-1 fusion inhibitors targeting gp41.

Published Nov 15, 2011 · Shibo Jiang, S. R. Tala, Hong Lu

Bioorganic & medicinal chemistry letters

Q2 SJR score

29

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1

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

The 2,5-disubstituted furans/pyrroles effectively inhibit HIV-1 infection and gp41 fusion, offering potential as a new class of anti-HIV-1 agents.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Design, synthesis, and biological activity of a novel series of 2,5-disubstituted furans/pyrroles as HIV-1 fusion inhibitors targeting gp41.

References

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