Design, Synthesis, and Anticancer Evaluation of 2-{3-{4-[(5-Aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl}isoxazol-5-yl}-N-(3,4,5-trimethylphenyl)thiazol-4-amine Derivatives

doi:10.1134/S1070363219070181

Paper

Design, Synthesis, and Anticancer Evaluation of 2-{3-{4-[(5-Aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl}isoxazol-5-yl}-N-(3,4,5-trimethylphenyl)thiazol-4-amine Derivatives

Published Jul 1, 2019 · T. Yakantham, R. Sreenivasulu, R. Raju

Russian Journal of General Chemistry

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26

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0

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Abstract

A series of new 2-{3-{4-[(5-aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl}isoxazol-5-yl}-N-(3,4,5-tri-methylphenyl)thiazol-4-amine derivatives is synthesized, and the structures of products are confirmed by 1H and 13C NMR, and mass spectra. The new compounds are tested for their anticancer activity against human cancer cell lines: MCF-7 (breast), A549 (lung), Du-145 (prostate), and MDA MB-231 (breast) by using MTT assay and etoposide as a standard reference. All compounds demonstrate good to moderate activity on all cell lines.

In Vitro Study

Study Snapshot

New 2-3-4-[(5-aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl-isoxazol-5-yl-N-(3,4,5-trimethylphenyl)thiazol-4-amine derivatives show good to

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Design, Synthesis, and Anticancer Evaluation of 2-{3-{4-[(5-Aryl-1,2,4-oxadiazol-3-yl)methoxy]phenyl}isoxazol-5-yl}-N-(3,4,5-trimethylphenyl)thiazol-4-amine Derivatives

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References

Erratum to: Second-Generation Tyrosine Kinase Inhibitors in First-Line Treatment of Chronic Myeloid Leukaemia (CML)

Dasatinib and nilotinib are more potent and effective than imatinib in first-line treatment of chronic myeloid leukemia, with a higher probability of optimal response.

Tandem synthesis and in vitro antiplasmodial evaluation of new naphtho[2,1-d]thiazole derivatives.

Two naphtho[2,1-d]thiazole derivatives show promising in vitro activity against the multiresistant K1 Plasmodium falciparum strain, with the R1 and R4 substituents influencing their biological profile.

An investigation of phenylthiazole antiflaviviral agents.

Phenylthiazole 12 shows high antiflaviviral selectivity without the toxic dibromomethyl moiety, offering a promising new class of antiviral agents for clinical use.

The new era of 1,2,4-oxadiazoles.

1,2,4-oxadiazoles show potential for use in materials and bioactive compounds, with potential for future development and applications.

Synthesis of new S-derivatives of clubbed triazolyl thiazole as anti-Mycobacterium tuberculosis agents.

New S-derivatives of clubbed triazolyl thiazole show moderate to better antitubercular activity against Mycobacterium tuberculosis H37 Rv strain, with potential for future antibacterial and antitubercular drugs.

Citations

Design, Synthesis and Biological various aryl derivatives of (pyridin-4-yl) imidazo[1,5-a]pyridin-1-yl)oxazoles as Anticancer agents

The new aryl derivatives of (pyridin-4-yl)imidazo[1,5-a]pyridin-1-yl)oxazoles show promising anticancer activity against various human cancer cell lines, with compound 10a showing the most promising activity.

Rational design, synthesis and biological evaluation of Isoxazole incorporated Oxazol-4-yl-1-(pyridin-4-yl)-1H-pyrazole as anticancer agents

Isoxazole-containing compounds 9a-j show promising anticancer activity against various human cancer cell lines, with compound 9b showing particularly potent activity.

Design, Synthesis and Anticancer Evaluation of Chalcone functionality bearing Benzothiazol-oxazole-pyrazine as Anticancer Agents

Compound 10j, a chalcone-bearing benzothiazol-oxazole-pyrazine derivative, showed potent anticancer activity against MCF-7, A549, Colo-205, and A2780 cell lines.

Synthesis of Substituted Aryl Incorporated Oxazolo[4,5-b]Pyridine-Triazole Derivatives: Anticancer Evaluation and Molecular Docking Studies

Substituted aryl incorporated oxazolo[4,5-b]pyridine-triazole derivatives show promising anticancer activities and efficient inhibition of human dihydroorotate dehydrogenase (hDHODH) in molecular docking studies.

Design, Synthesis and anticancer evaluation of 2-(5-(Benzo[d]thiazol-2-yl)-1H-imidazol-1-yl)-5-aryl-1H-benzo[d]imidazole derivatives

Compound 7b shows the highest anticancer activity against breast and lung cancer cell lines (MCF-7 and A549), with IC50 values of 0.018 0.0039 M and 0.011 0.0019 M, respectively.