Design, synthesis and anticancer properties of novel oxa/azaspiro[4,5]trienones as potent apoptosis inducers through mitochondrial disruption.

doi:10.1016/j.ejmech.2015.06.050

Paper

Design, synthesis and anticancer properties of novel oxa/azaspiro[4,5]trienones as potent apoptosis inducers through mitochondrial disruption.

Published Aug 28, 2015 · D. Yugandhar, D. Yugandhar, V. Nayak

European journal of medicinal chemistry

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50

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Abstract

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In Vitro Study

Study Snapshot

Novel oxa/azaspiro[4,5]trienone derivatives show promising anticancer properties by inducing mitochondrial-mediated apoptosis in human cancer cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Design, synthesis and anticancer properties of novel oxa/azaspiro[4,5]trienones as potent apoptosis inducers through mitochondrial disruption.

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