Paper
Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives
Published Jan 19, 2009 · Yi-sheng Xu, Chengchu Zeng, Zi-Guo Jiao
Molecules
Q1 SJR score
37
Citations
0
Influential Citations
Abstract
4-Oxo-4H-quinolizine-3-carboxylic acid derivatives bearing sulfamido, carboxylamido, benzimidazole and benzothiazole substituents have been designed and synthesized. The structures of these new compounds were confirmed by 1H-NMR, 13C- NMR, IR and ESI (or HRMS) spectra. Compounds were screened for possible HIV integrase inhibitory activity.
In Vitro StudyStudy Snapshot
4-Oxo-4H-quinolizine-3-carboxylic acid derivatives with sulfamido, carboxylamido, benzimidazole, and benzothiazole substituents show potential anti-HIV integrase inhibitory activity.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
Design, Synthesis and Anti‐HIV Integrase Evaluation of 1,2,3‐ Triazol‐4‐yl‐substituted 1,4‐Dihydro‐4‐oxo‐1,5‐napthyridine‐ 3‐carboxylic Acids
The 1,2,3-triazol-4-yl-substituted 1,4-dihydro-4-oxo-1,5-napthyridine-3-carboxylic acids show promising anti-HIV integrase activities, with potential for rapid creation and screening of a
2009·8citations·Jia Zeng et al.·Chinese Journal of Chemistry
Chinese Journal of Chemistry
Electrochemical synthesis of polyhydroxylated aromatic derivatives substituted with mono- and dipyrimidinyl thioethers in aqueous medium
Electrochemical oxidation of 4-substituted catechols and caffeic acid produces monopyrimidinylthio-substituted polyhydroxylated aromatics with potential anti-HIV integrase activity.
2008·17citations·Chengchu Zeng et al.·Journal of Electroanalytical Chemistry
Journal of Electroanalytical Chemistry
Organic Crystal Engineering with 1,4-Piperazine-2,5-diones. 7. Crystal Packing of Piperazinediones Derived from 2-Amino-7-nitro-4-methoxyindan-2-carboxylic Acid
1,4-Piperazine-2,5-diones derived from 2-amino-7-nitro-4-methoxyindan-2-carboxylic acid exhibit strong hydrogen bonding and one-dimensional tape structures, with a preference for parallel edge-to-center arene interactions in the
2008·8citations·Deogratias Ntirampebura et al.·Crystal Growth & Design
Crystal Growth & Design
Electrochemical synthesis of 6-arylsulfonyl caffeic acid derivatives in aqueous medium
Electrochemical oxidation of caffeic acid in the presence of sodium benzenesulfinate leads to the synthesis of 6-arylsulfonyl caffeic acid derivatives 7a or 7b.
2007·26citations·Chengchu Zeng et al.·Journal of Electroanalytical Chemistry
Journal of Electroanalytical Chemistry
A platform for designing HIV integrase inhibitors. Part 2: a two-metal binding model as a potential mechanism of HIV integrase inhibitors.
A two-metal binding model suggests Mg(2+) as an essential cofactor for designing HIV integrase inhibitors, with Mg(2+) playing a key role in preventing human DNA integration.
2006·80citations·T. Kawasuji et al.·Bioorganic & medicinal chemistry
Bioorganic & medicinal chemistry
Design, Synthesis and Cu2+ Recognition of β-Diketoacid and Quinoxalone Derivatives Bearing Caffeoyl or Galloyl Moieties Linked by Arylamide as Potential HIV Integrase Inhibitors
This study presents an efficient method for synthesis of caffeoyl- and galloyl-containing -diketoacid derivatives linked by arylamide, which show potential as HIV Integrase inhibitors.
2006·9citations·Yi-sheng Xu et al.·Chinese Journal of Chemistry
Chinese Journal of Chemistry
Sensing metal ions with DNA building blocks: fluorescent pyridobenzimidazole nucleosides.
Two novel fluorescent nucleosides can act as differential sensors for multiple metal ions, potentially contributing to DNA's metal ion sensing capability.
2006·49citations·S. J. Kim et al.·Journal of the American Chemical Society
Journal of the American Chemical Society
Organic crystal engineering with 1,4-piperazine-2,5-diones. 6. Studies of the hydrogen-bond association of cyclo[(2-methylamino-4,7-dimethoxyindan-2-carboxylic acid)(2-amino-4,7-dimethoxyindan-2-carboxylic acid)].
1,4-piperazine-2,5-dione crystallizes into polymorphic forms with different hydrogen-bonding networks, demonstrating similar association constants to other cyclic cis amides in chloroform solvent.
2005·27citations·Robin A Weatherhead-Kloster et al.·The Journal of organic chemistry
The Journal of organic chemistry
Design and synthesis of highly sensitive and selective fluorescein-derived magnesium fluorescent probes and application to intracellular 3D Mg2+ imaging.
The novel Mg2+ fluorescent probes KMG-101, -103, and -104 enable high-contrast, sensitive, and selective intracellular magnesium ion measurements, enabling dynamic and 3D imaging in cellular biology.
2004·138citations·Hirokazu Komatsu et al.·Journal of the American Chemical Society
Journal of the American Chemical Society
Citations
Synthesis of a new water-soluble highly Fe(III)-selective fluorescent chemosensor based on 4H-quinolizin-4-one
The new Fe(III)-selective fluorescent chemosensor based on 4H-quinolizin-4-one shows high sensitivity and selectivity for detection in aqueous mixtures, potentially aiding in diagnosis of ferric-related diseases.
2024·1citation·David Gallardo‐Rosas et al.·Journal of Molecular Structure
Journal of Molecular Structure
Rh(III)-Catalyzed C-H Activation/Annulation for the Construction of Quinolizinones and Indolizines.
Rh(III)-catalyzed C-H activation/anulation effectively creates biologically active quinolizinone and indolizine derivatives from readily available enamide and triazole substrates.
2024·1citation·Xinjiao Hou et al.·Organic letters
Organic letters
Discovery of New Ligand with Quinoline Scaffold as Potent Allosteric Inhibitor of HIV-1 and Its Copper Complexes as a Powerful Catalyst for the Synthesis of Chiral Benzimidazole Derivatives, and in Silico Anti-HIV-1 Studies
The novel Schiff base ligand with quinoline scaffold and its copper complexes show potential as potent anti-HIV-1 agents and catalysts for chiral benzimidazole synthesis.
2023·3citations·Sabikeh G Azimi et al.·Bioinorganic Chemistry and Applications
Bioinorganic Chemistry and Applications
Switching the Reactivity of the Nickel-Catalyzed Reaction of 2-Pyridones with Alkynes: Easy Access to Polyaryl/Polyalkyl Quinolinones.
Sodium iodide effectively switches the reactivity of nickel-catalyzed reactions, enabling the easy access to polyaryl/polyalkyl quinolinones from various substrates and alkynes.
2022·9citations·Namrata Prusty et al.·Organic letters
Organic letters
HFIP-promoted intramolecular dearomative annulation of pyridylacetate derivatives to access functionalized 3,4-dihydroquinolizin-2-ones
HFIP-promoted intramolecular dearomative annulation of 2-pyridylacetate derivatives successfully produces diverse substituted 3,4-dihydroquinolizin-2-ones with moderate to good yields under mild conditions.
2022·2citations·Yao-Bin Shen et al.·Tetrahedron
Tetrahedron
Palladium-catalyzed dearomative cyclocarbonylation of allyl alcohol for the synthesis of quinolizinones.
Palladium-catalyzed dearomative cyclocarbonylation of allyl alcohol efficiently synthesizes diverse quinolizinone compounds with potential bioactivity, offering a feasible reaction pathway for bioactive compounds.
2021·0citations·Pengcheng Xu et al.·Organic & biomolecular chemistry
Organic & biomolecular chemistry