Paper
Design; Synthesis and Antihypertensive activity of 4'-(2-{2-[(2-chloro-benzylidene)-amino]-phenyl}-5-nitro-benzoimidazol-1-ylmethyl)] biphenyl-2-carboxylic acid
Published 2010 · Manik Sharma, D. Kohli, Smita Sharma
International Journal of Advances in Pharmaceutical Sciences
3
Citations
0
Influential Citations
Abstract
In the present study, a series of 4`-(2-{2-[(2-chloro-benzylidene)-amino]-phenyl}-5-nitro-benzoimidazol-1-ylmethyl)] biphenyl-2-carboxylic acid derivatives are synthesized by A one-step coupling of substituted benzimidazoles with biphenyl carboxylic moiety mediated by potassium carbonate is described. The biphenyl carboxylic moiety was prepared from 9-H-fluorenone and substituted benzimidazoles were synthesized from o-phenylenediamine with anthranilic acid. Keywords: Benzimidazoles, biphenyl-2-carboxylic acid, angiotensin II, hypertension
4'-(2-2-[(2-chloro-benzylidene)-amino)-phenyl-5-nitro-benzoimidazol-1-ylmethyl)] biphenyl-2-carboxylic acid derivatives show antihypertensive activity when combined
Full text analysis coming soon...