Paper

Design, synthesis, and docking studies of phenylpicolinamide derivatives bearing 1H-pyrrolo[2,3-b]pyridine moiety as c-Met inhibitors.

Published Feb 15, 2016 · Wufu Zhu, Wenhui Wang, Shan Xu

Bioorganic & medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

Phenylpicolinamide derivatives bearing 1H-pyrrolo[2,3-b]pyridine moiety show excellent cytotoxicity activity and selectivity, with compound 15f showing superior activity to Foretinib against various cancer cell lines.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Design, synthesis, and docking studies of phenylpicolinamide derivatives bearing 1H-pyrrolo[2,3-b]pyridine moiety as c-Met inhibitors.

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