Design, synthesis, and biological evaluation of 1,3-diarylisoquinolines as novel topoisomerase I catalytic inhibitors.

doi:10.1016/j.ejmech.2017.11.011

Paper

Design, synthesis, and biological evaluation of 1,3-diarylisoquinolines as novel topoisomerase I catalytic inhibitors.

Published 2018 · D. B. Khadka, Seojeong Park, Yifeng Jin

European journal of medicinal chemistry

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11

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Abstract

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In Vitro Study

Study Snapshot

1,3-diarylisoquinolines show potent anti-proliferative effects on cancer cells, with potential as a promising class of anticancer agents due to their unique mechanism of action and absence of lethal effects on normal cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Design, synthesis, and biological evaluation of 1,3-diarylisoquinolines as novel topoisomerase I catalytic inhibitors.

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