Design, synthesis and anti-tubercular evaluation of new 2-acylated and 2-alkylated amino-5-(4-(benzyloxy)phenyl)thiophene-3-carboxylic acid derivatives. Part 1.

doi:10.1016/j.ejmech.2011.05.018

Paper

Design, synthesis and anti-tubercular evaluation of new 2-acylated and 2-alkylated amino-5-(4-(benzyloxy)phenyl)thiophene-3-carboxylic acid derivatives. Part 1.

Published Sep 1, 2011 · Xiaoyun Lu, Baojie Wan, S. Franzblau

European journal of medicinal chemistry

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44

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Abstract

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In Vitro Study

Study Snapshot

The designed 2-amino-5-phenylthiophene-3-carboxylic acid scaffold shows potential as a promising template for developing anti-TB drugs against MDR and XDR-TB strains with moderate activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Design, synthesis and anti-tubercular evaluation of new 2-acylated and 2-alkylated amino-5-(4-(benzyloxy)phenyl)thiophene-3-carboxylic acid derivatives. Part 1.

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