Design, synthesis and biological evaluation of 2-amino-4-(1,2,4-triazol)pyridine derivatives as potent EGFR inhibitors to overcome TKI-resistance.

doi:10.1016/j.ejmech.2019.111966

Paper

Design, synthesis and biological evaluation of 2-amino-4-(1,2,4-triazol)pyridine derivatives as potent EGFR inhibitors to overcome TKI-resistance.

Published Dec 14, 2019 · Haikui Yang, Ruohong Yan, Ying Jiang

European journal of medicinal chemistry

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17

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Abstract

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In Vitro Study

Study Snapshot

2-amino-4-(1,2,4-triazol)pyridine derivatives show potential as potent EGFR inhibitors, potentially overcoming TKI-resistance and showing anti-proliferative activity against various cancer cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Design, synthesis and biological evaluation of 2-amino-4-(1,2,4-triazol)pyridine derivatives as potent EGFR inhibitors to overcome TKI-resistance.

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