Design, synthesis and biological evaluation of lazabemide derivatives as inhibitors of monoamine oxidase.

doi:10.1016/j.bmc.2018.08.024

Paper

Design, synthesis and biological evaluation of lazabemide derivatives as inhibitors of monoamine oxidase.

Published Sep 1, 2018 · Shiyang Zhou, Guangying Chen, G. Huang

Bioorganic & medicinal chemistry

Q2 SJR score

14

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2

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Abstract

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In Vitro Study

Study Snapshot

Lazabemide derivatives effectively inhibit monoamine oxidase activity, increasing 5-HT, NE, and DA levels in plasma and brain tissue.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Design, synthesis and biological evaluation of lazabemide derivatives as inhibitors of monoamine oxidase.

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