Design, synthesis and biological evaluation of novel condensed pyrrolo[1,2-c]pyrimidines featuring morpholine moiety as PI3Kα inhibitors.

doi:10.1016/j.ejmech.2015.05.036

Paper

Design, synthesis and biological evaluation of novel condensed pyrrolo[1,2-c]pyrimidines featuring morpholine moiety as PI3Kα inhibitors.

Published Jun 24, 2015 · M. A. Ibrahim, S. M. Abou-Seri, Mona M. Hanna

European journal of medicinal chemistry

Q2 SJR score

20

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Abstract

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In Vitro Study

Study Snapshot

Morphino-pyrimidopyrrolopyrimidinones 8a-d and morpholino-pyridopyrrolopyrimidine-2-carbonitriles 12a-e are highly potent and selective PI3K inhibitors, with considerable cytotoxic activity against cervical cancer cells

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Design, synthesis and biological evaluation of novel condensed pyrrolo[1,2-c]pyrimidines featuring morpholine moiety as PI3Kα inhibitors.

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