[Design, synthesis and biological evaluation of novel 4-substituted-3-nitrobenzamide derivatives].

Paper

[Design, synthesis and biological evaluation of novel 4-substituted-3-nitrobenzamide derivatives].

Published Aug 1, 2014 · Qi-Feng Zhu, Yong-Xiang Gong, Jin-Qing Zhong

Yao xue xue bao = Acta pharmaceutica Sinica

Q3 SJR score

0

Citations

0

Influential Citations

Semantic Scholar

Abstract

A series of novel 4-substituted-3-nitrobenzamide derivatives were designed and synthesized. The structures of the target compounds were confirmed with 1H NMR, 13C NMR, MS and element analysis. Anti-tumor activities against HCT-116, MDA-MB435 and HL-60 cell lines in vitro were evaluated by SRB assay. The results indicated most of the target compounds exhibited potent anti-tumor activity. Compound 4a showed the most potent inhibitory activities against three cancer cell lines with the GI50 values of 1.904-2.111 micromol x L(-1). Compounds 4g, 41-4n exhibited more potent inhibitory activities against MDA-MB435 and HL-60 cell lines with the GI50 values of 1.008-3.586 micromol x L(-1) and 1.993-3.778 micromol x L(-1), respectively. The structure-activity relationship of these compounds is discussed preliminarily.

In Vitro Study

Study Snapshot

Novel 4-substituted-3-nitrobenzamide derivatives show potent anti-tumor activity against HCT-116, MDA-MB435 and HL-60 cancer cell lines.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

[Design, synthesis and biological evaluation of novel 4-substituted-3-nitrobenzamide derivatives].

Sign up to use Study Snapshot

References

Citations