Design, synthesis and biological evaluation of new 3-[(4-aryl)piperazin-1-yl]-1-arylpropane derivatives as potential antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-HT1A receptor antagonism.

doi:10.1016/S0014-827X(00)00050-1

Paper

DOI: 10.1016/S0014-827X(00)00050-1

Design, synthesis and biological evaluation of new 3-[(4-aryl)piperazin-1-yl]-1-arylpropane derivatives as potential antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-HT1A receptor antagonism.

Published May 1, 2000 · A. Oficialdegui, Javier Díez Martínez, S. Pérez

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Abstract

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In Vitro Study

Study Snapshot

New 3-[(4-aryl)piperazin-1-yl]-1-arylpropane derivatives show potential as antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-HT1A receptor antagonism.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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