Design, synthesis, and biological evaluation of arylpiperazine-benzylpiperidines with dual serotonin and norepinephrine reuptake inhibitory activities.

doi:10.1016/j.bmc.2016.03.044

Paper

DOI: 10.1016/j.bmc.2016.03.044

Design, synthesis, and biological evaluation of arylpiperazine-benzylpiperidines with dual serotonin and norepinephrine reuptake inhibitory activities.

Published May 1, 2016 · S. Paudel, Srijan Acharya, Kyeong-Man Kim

Bioorganic & medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

Arylpiperazine-benzylpiperidines show potential as a new class of therapeutic agents for treating neuropsychiatric and neurodegenerative disorders due to their dual serotonin and norepinephrine reuptake inhibitory activities.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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