Paper

Design, synthesis, molecular modeling, and biological evaluation of pyrazole-naphthalene derivatives as potential anticancer agents on MCF-7 breast cancer cells by inhibiting tubulin polymerization.

Published Jul 28, 2020 · Guangcheng Wang, Wenjing Liu, Zhiyun Peng

Bioorganic chemistry

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Abstract

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In Vitro Study

Study Snapshot

Pyrazole-naphthalene derivatives show potential anticancer activity against MCF-7 breast cancer cells, with compound 5j being five times more active than cisplatin, and inhibiting tubulin polymerization.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Design, synthesis, molecular modeling, and biological evaluation of pyrazole-naphthalene derivatives as potential anticancer agents on MCF-7 breast cancer cells by inhibiting tubulin polymerization.

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