Design, Synthesis, Molecular Docking, and Antimicrobial Activity of N-{(E)-[2-(Morpholin-4-yl)quinolin-3-yl]methylidene}aniline Derivatives

doi:10.1134/S1070428020030203

Paper

Design, Synthesis, Molecular Docking, and Antimicrobial Activity of N-{(E)-[2-(Morpholin-4-yl)quinolin-3-yl]methylidene}aniline Derivatives

Published Mar 1, 2020 · D. Subhash, K. Bhaskar

Russian Journal of Organic Chemistry

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Abstract

A series of novel (E)-N-{[2-(morpholin-4-yl)quinolin-3-yl]methylidene}aniline derivatives have been designed and synthesized by the reaction of 2-(morpholin-4-yl)quinoline-3-carbaldehyde with substituted anilines. The synthesized compounds were evaluated for their in vitro antimicrobial activity against various microorganisms, and molecular docking study was also performed. Some derivatives exhibited a significant activity against bacterial and fungal strains. The molecular docking study has shown the best dock score for (E)-N-(4-methylphenyl)-1-[2-(morpholin-4-yl)quinolin-3-yl]methanimine in comparison to amoxicillin.

In Vitro Study

Study Snapshot

Novel (E)-N-[2-(morpholin-4-yl)quinolin-3-yl]methylidene-aniline derivatives show significant antimicrobial activity against various microorganisms, with (E)-N-(4-methylphenyl)-1-[2-(morph

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Design, Synthesis, Molecular Docking, and Antimicrobial Activity of N-{(E)-[2-(Morpholin-4-yl)quinolin-3-yl]methylidene}aniline Derivatives

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