Design, synthesis and molecular modelling studies of novel 3-acetamido-4-methyl benzoic acid derivatives as inhibitors of protein tyrosine phosphatase 1B.

doi:10.1016/j.ejmech.2013.10.030

Paper

Design, synthesis and molecular modelling studies of novel 3-acetamido-4-methyl benzoic acid derivatives as inhibitors of protein tyrosine phosphatase 1B.

Published Dec 1, 2013 · Monika Rakse, C. Karthikeyan, G. S. Deora

European journal of medicinal chemistry

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21

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Abstract

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In Vitro Study

Study Snapshot

Novel 3-acetamido-4-methyl benzoic acid derivatives show maximum PTP1B inhibitory activity, with compounds 10c and 10e showing the highest activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Design, synthesis and molecular modelling studies of novel 3-acetamido-4-methyl benzoic acid derivatives as inhibitors of protein tyrosine phosphatase 1B.

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