A series of 4,5,6,7-tetrahydrothieno[3,2-c]pyridine derivatives have been synthesized and evaluated for their activity on the activation of human complement (classical pathway) and their intrinsic haemolytic activity. The in vitro assay results of these analogues for inhibition of complement activity reveals improved inhibitory activity for some of the analogues over existing tetrahydrothienopyridine derivatives like Ticlopidine and Clopidogrel. Significantly, these analogues did not exhibit any haemolytic activity and are non-cytotoxic to human cell lines.

These 4,5,6,7-tetrahydrothieno[3,2-c]pyridine derivatives show improved complement inhibition activity without exhibiting haemolytic activity and are non-cytotoxic to human cell lines.

Paper

Design and Synthesis of Non-cytotoxic Tetrahydrothieno[3,2-c]pyridine Derivatives Exhibiting Complement Inhibition Activity.

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