Paper

Design and synthesis of a novel series of 4-heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes as α7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR.

Published Mar 1, 2017 · Christiana I. Iwuagwu, D. King, I. Mcdonald

Bioorganic & medicinal chemistry letters

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Abstract

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Study Snapshot

This study developed a novel series of 7 nicotinic receptor agonists, which show potential in improving cognition in the mouse novel object recognition model.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Design and synthesis of a novel series of 4-heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes as α7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR.

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