Design, Synthesis and Pharmacological Evaluation of a Series of 5-Carbethoxy-4-chloro-6-(substituted amino)pyrimidines as Potential Analgesic and Anti-flammatory Agents with Very Low Ulcerogenic Potential

doi:10.1055/s-0031-1296407

Paper

Design, Synthesis and Pharmacological Evaluation of a Series of 5-Carbethoxy-4-chloro-6-(substituted amino)pyrimidines as Potential Analgesic and Anti-flammatory Agents with Very Low Ulcerogenic Potential

Published Jul 1, 2009 · M. Chhabria, C. Shishoo, Dilip K. Vaghela

Arzneimittelforschung

UNKNOWN SJR score

3

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

Abstract A series of 5-carbethoxy-4-chloro-6-(substituted amino)pyrimidines was designed on the basis of its good 3-dimensional structural similarity with mefenamic acid (CAS 61-68-7), a well known anti-inflammatory drug. Synthesis of some 5-carbethoxy-4-chloro-6-(substitutedamino) pyrimidines has been achieved by cyclization of N-(cyanovinyl)formamidine intermediate in the presence of dry HCl. Target compounds were evaluated for their analgesic and anti-inflammatory potential by known experimental models. Some of the compounds emerged as more potent analgesic and anti-inflammatory agents than the standard drug diclofenac sodium (CAS 15307-79-6). A very low ulcer index was observed with the most potent compound.

In Vitro Study

Study Snapshot

A series of 5-carbethoxy-4-chloro-6-(substituted amino)pyrimidines show potential as more potent analgesic and anti-inflammatory agents than diclofenac sodium, with a very low ulcerogenic potential.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Design, Synthesis and Pharmacological Evaluation of a Series of 5-Carbethoxy-4-chloro-6-(substituted amino)pyrimidines as Potential Analgesic and Anti-flammatory Agents with Very Low Ulcerogenic Potential

References

Citations