Paper

Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors.

Published Apr 23, 2001 · A. Clemente, A. Domingos, A. P. Grancho

Bioorganic & medicinal chemistry letters

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Abstract

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Study Snapshot

N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones show inhibitory potency and selectivity for human leukocyte elastase, offering potential mechanism-based inhibitors.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors.

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