Design, synthesis, structure activity relationship and molecular docking studies of thiophene-2-carboxamide Schiff base derivatives of benzohydrazide as novel acetylcholinesterase and butyrylcholinesterase inhibitors

doi:10.1016/J.MOLSTRUC.2021.130983

Paper

Design, synthesis, structure activity relationship and molecular docking studies of thiophene-2-carboxamide Schiff base derivatives of benzohydrazide as novel acetylcholinesterase and butyrylcholinesterase inhibitors

Published Nov 15, 2021 · N. Kausar, S. Murtaza, M. Arshad

Journal of Molecular Structure

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Abstract

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In Vitro Study

Study Snapshot

Novel thiophene-2-carboxamide Schiff base derivatives of benzohydrazide show promising potential as effective dual cholinesterase inhibitors and antioxidants.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Design, synthesis, structure activity relationship and molecular docking studies of thiophene-2-carboxamide Schiff base derivatives of benzohydrazide as novel acetylcholinesterase and butyrylcholinesterase inhibitors

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