Design, synthesis, and structure-activity relationship study of bicyclic piperazine analogs of indole-3-carboxamides as novel cannabinoid CB1 receptor agonists.

doi:10.1016/j.bmcl.2010.10.061

Paper

Design, synthesis, and structure-activity relationship study of bicyclic piperazine analogs of indole-3-carboxamides as novel cannabinoid CB1 receptor agonists.

Published Dec 15, 2010 · E. Moir, K. Yoshiizumi, J. Cairns

Bioorganic & medicinal chemistry letters

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21

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Abstract

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In Vitro Study

Study Snapshot

Bicyclic piperazine derivatives are potent CB1 receptor agonists, with some showing potent antinociceptive activity in vivo.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Design, synthesis, and structure-activity relationship study of bicyclic piperazine analogs of indole-3-carboxamides as novel cannabinoid CB1 receptor agonists.

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