Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials.

doi:10.1016/j.bmcl.2009.05.017

Paper

DOI: 10.1016/j.bmcl.2009.05.017

Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials.

Published Jul 1, 2009 · Tiago Rodrigues, R. Guedes, Daniel J. V. A. dos Santos

Bioorganic & medicinal chemistry letters

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Abstract

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In Vitro Study

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(1H-pyridin-4-ylidene)amines show potential as antimalarials, with the most active derivative, 4m, showing 1 M IC50 against W2 and 3 M against FCR3.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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