Paper

Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs.

Published Nov 6, 2013 · Lingzi Zhang, P. Zhan, Xuwang Chen

Bioorganic & medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

Novel N-arylmethyl substituted piperidine-linked aniline derivatives show moderate to potent anti-HIV activity, with compound 5a6 being the most potent and selective inhibitor.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs.

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