Paper
Desonide: a review of formulations, efficacy and safety.
Published Jun 12, 2008 · DOI · Nr Kahanek, C. Gelbard, A. Hebert
Expert opinion on investigational drugs
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Abstract
BACKGROUND Desonide is a low-potency topical corticosteroid that has been used for decades in the treatment of steroid-responsive dermatoses. The favorable safety profile of this topical agent makes it ideal for patients of all ages. OBJECTIVE This article provides a review of desonide's history, pharmacodynamic properties, vehicle technology, efficacy and safety. METHODS Randomized controlled trials, as well as open-label and non-comparative studies, case series and reports, experimental models, and data from the Galderma pharmacovigiliance program were reviewed in order to address the clinical efficacy and safety of desonide. RESULTS/CONCLUSION Clinical efficacy and safety have been proven in multiple clinical trials. In addition to cream, lotion and ointment formulations, the recently developed hydrogel and foam preparations have increased desonide's versatility and patient tolerability.
Desonide is a low-potency topical corticosteroid with proven clinical efficacy and safety, and its versatility and patient tolerability have been enhanced by hydrogel and foam preparations.
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