Development of a concise and general enantioselective approach to 2,5-disubstituted-3-hydroxytetrahydrofurans.

doi:10.1021/ol802711s

Paper

Development of a concise and general enantioselective approach to 2,5-disubstituted-3-hydroxytetrahydrofurans.

Published Mar 26, 2009 · Baldip Kang, J. Mowat, Thomas Pinter

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Abstract

Concise syntheses of 2,5-disubstituted-3-hydroxytetrahydrofurans have been developed that provide access to each configurational isomer of this scaffold from a single aldol adduct. Application of these methods to the rapid preparation of (6S,7S,9S,10S)- and (6S,7S,9R,10R)-6,9-epoxynonadec-18-ene-7,10-diol, two structurally related marine epoxylipids, is reported.

Study Snapshot

This study developed a concise enantioselective approach for 2,5-disubstituted-3-hydroxytetrahydrofurans, enabling rapid preparation of marine epoxylipids (6S,7S,9S,10S) and (6S,7R,10R)-6,

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Development of a concise and general enantioselective approach to 2,5-disubstituted-3-hydroxytetrahydrofurans.

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References

Citations

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