Abstract The trimethylsilyl (TMS) group is widely used in carbohydrate synthesis, although this protecting group is unstable and its post-synthetic purification challenging. The successful trimethylsilylation of carbohydrates mediated by recyclable and efficient acidic catalyst PTA/HMDS and the novel reagent, TMSOAc (TEA/TMSOAc), under alkaline condition is reported. The advantages of these methods are that the reactions proceed in good to excellent yields without applying column chromatography for purification.

This study successfully developed a novel method for trimethylsilylation of carbohydrates using recyclable acidic catalyst PTA/HMDS and novel reagent TMSOAc, resulting in good to excellent yields without column chromatography.

Paper

Development of a Novel Method for Trimethylsilylation of Saccharides

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