Recent Developments in the Synthesis of Imidazo[1,2-a]pyridines

doi:10.1055/S-0034-1380182

Paper

Recent Developments in the Synthesis of Imidazo[1,2-a]pyridines

Published Feb 26, 2015 · Kasiviswanadharaju Pericherla, P. Kaswan, Khima Pandey

Synthesis

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141

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Abstract

Advances in the last decade for the synthesis of the imidazo[1,2-a]pyridine scaffold from various substrates employing approaches such as multicomponent reactions, tandem processes, rearrangement reactions, inter- and intramolecular oxidative/reductive cyclizations, and transition-metal-catalyzed C–H activation are summarized in this review. The mechanisms for the selected transformations are also discussed. 1 Introduction 2 From 2-Aminopyridines 2.1 Revisiting Traditional Cyclocondensation 2.1.1 Regioselectivity in Cyclocondensation 2.2 Reactions of Carbonyl Compounds 2.3 Reactions of α,β-Unsaturated Carbonyl Compounds 2.4 Reactions of Nitroolefins 2.5 Reactions of Alkynes 2.6 Multicomponent Reactions 2.6.1 Three-Component Reaction of Aldehyde, 2-Aminopyridine, and Isocyanide 2.6.2 Three-Component Reaction of 2-Aminopyridine, Aldehyde, and Alkyne 2.6.3 Other Multicomponent Procedures 2.7 Reactions of N-Substituted 2-Aminopyridines 2.8 Miscellaneous Reactions 3 From Pyridines 3.1 Multicomponent Reactions 4 From Pyridinium Salts 5 From Imidazoles 5.1 Reactions of Heterocyclic Ketene Aminals 6 Miscellaneous Methods 7 Conclusion

Highly Cited

Study Snapshot

Recent advances in imidazo[1,2-a]pyridine synthesis from various substrates using multicomponent reactions, tandem processes, rearrangement reactions, oxidative/reductive cyclizations, and transition-metal-catalyzed C-H activation provide promising pathways for their applications.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Recent Developments in the Synthesis of Imidazo[1,2-a]pyridines

References

Citations

Synthesis of a novel imidazo[1,2-a]pyridines derivative as high selective fluorescent sensor for cyanide detection

The novel imidazo[1,2-a]pyridine derivative (IP) is a highly sensitive and selective fluorescent chemosensor for cyanide ions, with a rapid response time of 40 seconds and a low detection limit of 30 nM.

Synthesis, Characterization, and antiviral evaluation of New Chalcone-Based Imidazo[1,2-a]pyridine Derivatives: Insights from in vitro and in silico Anti-HIV studies.

New Chalcone-based imidazo[1,2-a]pyridine derivatives show promising antiviral properties against HIV-1 and HIV-2, with potential for further structural optimization to enhance bioavailability and therapeutic potential.

Synthesis, crystal structure, and antiviral evaluation of new imidazopyridine-schiff base derivatives: in vitro and in silico anti-HIV studies

New imidazopyridine-schiff base derivatives show promising antiviral activity against HIV-1 and HIV-2, but require further structural modifications for enhanced bioavailability and therapeutic potential.

Synthesis of 6- or 8-Carboxamido Derivatives of Imidazo[1,2-a]pyridines via a Heterogeneous Catalytic Aminocarbonylation Reaction

Pd-catalyzed carbonylation efficiently synthesizes 6- or 8-carboxamido derivatives of imidazo[1,2-a]pyridines, with excellent recyclability and low Pd-leaching.

An ESIPT-active orange-emissive 2-(2′-hydroxyphenyl)imidazo[1,2-a]pyridine-derived chemodosimeter for turn-on detection of fluoride ions via desilylation

The HIPS-Br chemodosimeter effectively detects fluoride ions in water sources, offering a low limit of detection of 1.2 ppb for on-site quantitation.

The synthesis of Fe3O4@SiO2-NNO-CuII nanocatalyst and investigation of its application in the synthesis of imidazo[1,2-a]pyridines

The Fe3O4@SiO2-NNO-CuII nanocatalyst efficiently recycles copper ions for the synthesis of imidazo[1,2-a]pyridines in high yields and short reaction times.

Imidazo[1,2-a]pyridine-appended chalcone and Schiff base conjugates: synthetic, spectrophotometric, biological, and computational aspects

Imidazo[1,2-a]pyridine-appended chalcone and Schiff base conjugates show potential as antibacterial and anti-lung cancer agents, with potential for further development as promising intrants.

Imidazopyridine Family: Versatile and Promising Heterocyclic Skeletons for Different Applications

The imidazopyridine family offers versatile and promising heterocycles for various applications, ranging from material science to pharmaceuticals, with unique properties and diverse biological attributes.

Recent Advances in Metal-Catalyzed Approaches for the Synthesis of Quinazoline Derivatives

Transition metal-catalyzed reactions have advanced new synthetic methods for quinazoline derivatives, offering potential for organic synthesis and medicinal chemistry applications.