Paper
Le (−)-(2S)-2-hydroxyhexanedioate de diéthyle, nouveau bloc chiral pour la synthèse énantiospécifique
Published Jan 30, 1991 · Florian Blaser, Pierre‐François Deschenaux, Thomas Kallimopoulos
Helvetica Chimica Acta
11
Citations
1
Influential Citations
Abstract
The (−)-(2S)-Diethyl 2-Hydroxyhexanedioate, a New Chiral Building Block for Enantioselective Synthesis (−)-(2S)-Diethyl 2-hydroxyhexanedioate ((2S)-3) has been obtained by enantioselective reduction of diethyl 2-oxohexanedioate (1) with baker's yeast. The key intermediate (−)-(5S)-ethyl 5,6-dihydroxyhexanoate ((5S)-5) is proved to be a useful synthon for the synthesis of chiral δ-lactones and a precursor of leukotriene LTB4 ((5S)-13).
The ()-(2S)-Diethyl 2-Hydroxyhexanedioate ((2S)-3) is a new chiral building block for enantioselective synthesis, providing a useful intermediate for chiral -lactone
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