Dihydroergotamine and its metabolite, 8′‐hydroxy‐dihydroergo‐tamine, as 5‐HT1A receptor agonists in the rat brain

doi:10.1038/sj.bjp.0705258

Paper

Dihydroergotamine and its metabolite, 8′‐hydroxy‐dihydroergo‐tamine, as 5‐HT1A receptor agonists in the rat brain

Published May 1, 2003 · N. Hanoun, F. Saurini, Laurence Lanfumey

British Journal of Pharmacology

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Abstract

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In Vitro Study

Study Snapshot

Dihydroergotamine and its metabolite 8′-hydroxy-dihydroergo-tamine, both 5HT1A receptor agonists, can inhibit neuronal excitability and anxiolytic effects, potentially contributing to their antimigraine prophylactic efficiency.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Dihydroergotamine and its metabolite, 8′‐hydroxy‐dihydroergo‐tamine, as 5‐HT1A receptor agonists in the rat brain

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