Dilithium Amides as a Modular Bis-Anionic Ligand Platform for Iron-Catalyzed Cross-Coupling.

doi:10.1021/acs.orglett.1c02053

Paper

Dilithium Amides as a Modular Bis-Anionic Ligand Platform for Iron-Catalyzed Cross-Coupling.

Published Jul 26, 2021 · Peter G. N. Neate, Bufan Zhang, Jessica Conforti

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Abstract

Dilithium amides have been developed as a bespoke and general ligand for iron-catalyzed Kumada-Tamao-Corriu cross-coupling reactions, their design taking inspiration from previous mechanistic and structural studies. They allow for the cross-coupling of alkyl Grignard reagents with sp2-hybridized electrophiles as well as aryl Grignard reagents with sp3-hybridized electrophiles. This represents a rare example of a single iron-catalyzed system effective across diverse coupling reactions without significant modification of the catalytic protocol, as well as remaining operationally simple.

Study Snapshot

Dilithium amides enable efficient cross-coupling of alkyl Grignard reagents with sp2-hybridized electrophiles and aryl Grignard reagents with sp3-hybridized electrophiles, offering a unique and simple

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Dilithium Amides as a Modular Bis-Anionic Ligand Platform for Iron-Catalyzed Cross-Coupling.

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References

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Citations

Kumada–Tamao–Corriu Type Reaction of Aromatic Bromo- and Iodoamines with Grignard Reagents

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This study presents a novel method for synthesis of benzylic alcohols using iron-catalyzed cross-coupling and chemoselective reduction of benzamides, enabling underexplored avenues in organic synthesis and medicinal chemistry.

Recent Advances in Non-Precious Metal Catalysis

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