Dimethoxyboron bromide, (MeO)2BBr, easily prepared in excellent yield from boron tribromide and trimethyl borate, is a new, efficient, regio- and chemoselective reagent useful for the halogenative cleavage of compounds containing epoxy groups into vicinal bromohydrins in the presence of ether, acetal, ketal, N-oxide, and sulfoxide groups, at low temperatures (–78°C).

Dimethoxyboron bromide is a promising reagent for converting terminal epoxides into bromohydrins at low temperatures, with potential applications in organic synthesis and catalysis.

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Dimethoxyboron bromide – a new, efficient, regio- and chemoselective reagent for the conversion of terminal epoxides into bromohydrins

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