Paper
Dimethyl 2-{3,3-Bis(methoxycarbonyl)bicyclo[2.2.1]hept-5-en-2-yl}malonate. Synthesis and Base-Catalyzed C–C Bond Cleavage Reaction
Published Jul 1, 1994 · K. Kitano, N. Katagiri, C. Kaneko
Chemistry Letters
Q2 SJR score
3
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0
Influential Citations
Abstract
The reaction of cyclopentadiene with 1,1,3,3-tetrakis(methoxycarbonyl)propene gives an endo and exo mixture of dimethyl 2-{3,3-bis(methoxycarbonyl)bicyclo-[2.2.1]hept-5-en-2-yl}malonate, which by base-mediated retro-Michael reaction gives stereoselectively the cis-isomer of dimethyl 2-{4-[2,2-bis(methoxycarbonyl)vinyl]cyclopent-2-en-1-yl}malonate.
Study Snapshot
Base-mediated retro-Michael reaction allows for the stereoselective synthesis of dimethyl 2-3,3-bis(methoxycarbonyl)bicyclo[2.2.1]hept-5-en-2-ylmalonate, a key intermediate in the synthesis of cycl
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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