Dipyrone is locally hydrolyzed to 4-methylaminoantipyrine and its antihyperalgesic effect depends on CB2 and kappa-opioid receptors activation.

doi:10.1016/j.ejphar.2020.173005

Paper

DOI: 10.1016/j.ejphar.2020.173005

Dipyrone is locally hydrolyzed to 4-methylaminoantipyrine and its antihyperalgesic effect depends on CB2 and kappa-opioid receptors activation.

Published Feb 11, 2020 · Gilson Gonçalves dos Santos, W. Vieira, P. Vendramini

European journal of pharmacology

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Abstract

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Non-RCT

Animal Study

Rigorous Journal

Study Snapshot

Dipyrone's local analgesic effect depends on CB2 and kappa-opioid receptor activation, with its hydrolyzed form 4-MAA acting as a potential mediator in peripheral tissue.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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