Discovery of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers. 2. Identification of more aqueous soluble analogs as potential anticancer agents.

doi:10.1016/j.bmcl.2009.05.052

Paper

Discovery of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers. 2. Identification of more aqueous soluble analogs as potential anticancer agents.

Published Aug 1, 2009 · William E. Kemnitzer, J. Kuemmerle, Han-Zhong Zhang

Bioorganic & medicinal chemistry letters

Q2 SJR score

44

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0

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Abstract

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Study Snapshot

The 3-aryl-5-aryl-1,2,4-oxadiazole series of apoptosis inducers shows potential as anticancer agents, with compounds 4g and 4h showing improved solubility and in vivo efficacy in animal studies.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Discovery of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers. 2. Identification of more aqueous soluble analogs as potential anticancer agents.

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