Discovery of new chromone containing sulfonamides as potent inhibitors of bovine cytosolic carbonic anhydrase.

doi:10.1016/j.bmc.2011.04.040

Paper

DOI: 10.1016/j.bmc.2011.04.040

Discovery of new chromone containing sulfonamides as potent inhibitors of bovine cytosolic carbonic anhydrase.

Published Jun 1, 2011 · Mariya al‐Rashida, M. Ashraf, Bushra Hussain

Bioorganic & medicinal chemistry

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

New chromone-containing sulfonamides show excellent inhibitory activity against bovine carbonic anhydrase, with compounds derived from 6-fluoro-3-formylchromones being the most active.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Targeting Carbonic Anhydrases II/ IX/ XII with Novel Series of Coumarin-Based Compounds: Synthesis, Biological Activity and Molecular Dynamics Analysis

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Synthesis, Characterization, and Evaluation of in vitro Antidiabetic Activity of Novel Pyrrolidine Sulphonamide Derivative

Novel 1,2,4-oxadiazole derivatives with sulfonamide and pyrrolidine-2-carbonitrile scaffolds show potential as potent DPP-IV inhibitors for antidiabetic activity.

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Synthesis of novel hybrid pharmacophore of N‐((4‐sulfamoylphenyl)carbamothioyl)alkanamides as potent carbonic anhydrase‐II and 15‐lipoxygenase inhibitors

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Rational design and synthesis of new tetralin-sulfonamide derivatives as potent anti-diabetics and DPP-4 inhibitors: 2D & 3D QSAR, in vivo radiolabeling and bio distribution studies.

New tetralin-sulfonamide derivatives show potential as potent anti-diabetic and DPP-4 inhibitors, with promising bio distribution patterns and selective accumulation in the pancreas.

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