Discovery of highly selective 7-chloroquinoline-thiohydantoins with potent antimalarial activity.

doi:10.1016/j.ejmech.2014.07.048

Paper

Discovery of highly selective 7-chloroquinoline-thiohydantoins with potent antimalarial activity.

Published Sep 12, 2014 · R. Raj, Vishu Mehra, J. Gut

European journal of medicinal chemistry

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27

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Abstract

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In Vitro Study

Study Snapshot

7-chloroquinoline-thiohydantoin derivatives show potent antimalarial activity, with the most potent and non-cytotoxic compound showing an IC 50 of 39.8 nM, suggesting inhibition of haemozoin formation as a primary mechanism of action.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Discovery of highly selective 7-chloroquinoline-thiohydantoins with potent antimalarial activity.

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