Paper
Discovery of novel spiro[chromane-2,4'-piperidine] derivatives as potent and orally bioavailable G-protein-coupled receptor 119 agonists.
Published Oct 1, 2018 · Tomoaki Koshizawa, T. Morimoto, Gen Watanabe
Bioorganic & medicinal chemistry letters
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10
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0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
The novel spiro[chromane-2,4′-piperidine] derivatives (R)-29 show potent and orally bioavailable G-protein-coupled receptor 119 agonist activity, reducing glucose excursion in mice in a dose-dependent manner.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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