Paper

Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO).

Published Aug 14, 2020 · DOI · Shulei Pan, Yangli Zhou, Qiusheng Wang

European journal of medicinal chemistry

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Abstract

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In Vitro Study

Study Snapshot

1-(3-chloro-4-fluorophenyl)-6-fluoro-1 H-naphtho[2,3-d][1,2,3]triazole-4,9-dione (38) shows potent dual inhibitory activities of IDO1 and TDO, showing

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Discovery and structure-activity relationship studies of 1-aryl-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione derivatives as potent dual inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1) and trytophan 2,3-dioxygenase (TDO).

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