Discovery and structure-activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists.

doi:10.1016/J.BMCL.2004.11.071

Paper

Discovery and structure-activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists.

Published Feb 15, 2005 · Wu Yang, Yufeng Wang, J. Y. Roberge

Bioorganic & medicinal chemistry letters

Q2 SJR score

41

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1

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Abstract

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In Vitro Study

Study Snapshot

3h, a substituted 2-benzylpyrrolidine, shows potential as a calcium-sensing receptor antagonist with a better human ether-a-go-go related gene profile than NPS-2143.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Discovery and structure-activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists.

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