Discovery of substituted 4-anilino-2-(2-pyridyl)pyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Part 1: structure-activity relationships of the 4-anilino group.

doi:10.1016/J.BMC.2006.08.002

Paper

Discovery of substituted 4-anilino-2-(2-pyridyl)pyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Part 1: structure-activity relationships of the 4-anilino group.

Published Dec 1, 2006 · N. Sirisoma, S. Kasibhatla, Bao N. Nguyen

Bioorganic & medicinal chemistry

Q2 SJR score

42

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1

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Abstract

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In Vitro Study

Study Snapshot

Substituted 4-anilino-2-(2-pyridyl)pyrimidines show potential as potent apoptosis inducers, with potential applications in cancer therapy and cell death research.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Discovery of substituted 4-anilino-2-(2-pyridyl)pyrimidines as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. Part 1: structure-activity relationships of the 4-anilino group.

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