Discovery, synthesis and molecular corroborations of medicinally important novel pyrazoles; drug efficacy determinations through in silico, in vitro and cytotoxicity validations.

doi:10.1016/j.bioorg.2019.02.003

Paper

Discovery, synthesis and molecular corroborations of medicinally important novel pyrazoles; drug efficacy determinations through in silico, in vitro and cytotoxicity validations.

Published May 1, 2019 · P. Thangarasu, A. Manikandan, S. Thamaraiselvi

Bioorganic chemistry

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16

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Abstract

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In Vitro Study

Study Snapshot

Novel pyrazole carbaldehyde derivatives show potential as COX-2 inhibitors and anti-inflammatory drugs, with potential applications in cancer and inflammation treatments.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Discovery, synthesis and molecular corroborations of medicinally important novel pyrazoles; drug efficacy determinations through in silico, in vitro and cytotoxicity validations.

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