Dose-response studies in carcinogenesis by nitroso-N-methyl-N-(2-phenyl)ethylamine in rats and the effects of deuterium substitution.

doi:10.1016/S0278-6915(82)80103-8

Paper

Dose-response studies in carcinogenesis by nitroso-N-methyl-N-(2-phenyl)ethylamine in rats and the effects of deuterium substitution.

Published 1982 · W. Lijinsky, M. D. Reuber, T. Davies

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

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9

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Abstract

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Non-RCT

Animal Study

Study Snapshot

Nitroso-N-methyl-N-(2-phenyl)ethylamine carcinogenesis in rats is significantly increased when deuterium is substituted in the -methylene of the phenylethyl group, suggesting methylation may not be the key event in carcinogenesis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Dose-response studies in carcinogenesis by nitroso-N-methyl-N-(2-phenyl)ethylamine in rats and the effects of deuterium substitution.

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References

Dose response studies of carcinogenesis in rats by nitrosodiethylamine.

Nitrosodiethylamine, when administered for 104 weeks, can induce tumors in the upper gastrointestinal tract in 70% of treated rats, with liver tumors also present at higher doses.

The effect of deuterium labeling on the carcinogenicity of nitroso-2,6-dimethylmorpholine in rats.

Deuterium in alpha positions decreases carcinogenic potency, while deuterium in beta positions increases it, suggesting oxidation at beta carbon atoms is less likely to contribute to esophageal carcinogenesis.

The effect of deuterium on the carcinogenicity of nitroso-methyl-n-butylamine.

Deuterium in the methyl group of nitroso-methyl-n-butylamine increases its carcinogenicity, while deuterium in the butyl group reduces it.

Trend and homogeneity analyses of proportions and life table data.

This FORTRAN program can compute various statistical tests relating proportions to dose, including linear trend tests, homogeneity tests, and time-adjusted trend tests.

Histopathology of preneoplastic and neoplastic lesions of the esophagus in BUF rats ingesting diethylnitrosamine.

Diethylnitrosamine-induced esophageal carcinomas in BUF rats showed various stages and did not metastasize, suggesting potential carcinogenicity in humans.

Citations