Paper
Intact Doxil is taken up intracellularly and released doxorubicin sequesters in the lysosome: evaluated by in vitro/in vivo live cell imaging.
Published Nov 28, 2013 · A. Seynhaeve, B. Dicheva, S. Hoving
Journal of controlled release : official journal of the Controlled Release Society
Q1 SJR score
135
Citations
5
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro Study
Highly CitedStudy Snapshot
Doxil, a liposomal doxorubicin formulation, is taken up by tumor cells and slowly degraded, making it less effective in killing tumor cells compared to free doxorubicin.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Cationic thermosensitive liposomes: a novel dual targeted heat-triggered drug delivery approach for endothelial and tumor cells.
Cationic thermosensitive liposomes effectively target angiogenic endothelial and tumor cells, allowing rapid content release under mild hyperthermia for targeted chemotherapy.
2013·115citations·B. Dicheva et al.·Nano letters
Nano letters
A simple way to enhance Doxil® therapy: drug release from liposomes at the tumor site by amphiphilic block copolymer.
Adding Pluronic P85 to Doxil® therapy at the tumor site significantly enhances drug release and cytotoxic effect, improving therapeutic efficacy in cancer treatment.
2013·109citations·Yi Zhao et al.·Journal of controlled release : official journal of the Controlled Release Society
Journal of controlled release : official journal of the Controlled Release Society
Improving Intracellular Doxorubicin Delivery Through Nanoliposomes Equipped with Selective Tumor Cell Membrane Permeabilizing Short-Chain Sphingolipids
Nanoliposomes incorporating C_8-GluCer or C_8-GalCer significantly improve intracellular doxorubicin delivery and cytotoxicity in tumor cells by enhancing cell membrane permeability.
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Journal of controlled release : official journal of the Controlled Release Society
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